:: Volume 21, Number 3 (5-2017) ::
IBJ 2017, 21(3): 197-202 Back to browse issues page
Comparing Anti-hepatitis B Antibody Level in Iranian Obese or Overweight with Non-obese Cases
Ali Kabir, Abdolreza Pazouki , Motahareh Jafari, Somayye Mokhber, Mohammad Vaziri, Seyed Moayed Alavian
Abstract:  

Background: There is a controversy about the relation between anti-hepatitis B (anti-HBs) antibody level and obesity. We designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases. Methods: In this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. Cases were selected from a referral clinic for obesity and a referral hepatology clinic, both in Tehran, Iran.
Results: Obese cases had lower percentage of liver diseases (66.9% vs. 100%, P<0.001) but higher hepatitis B vaccination history (74.9% vs. 51.2%, P<0.001). Median±inter-quartile range of anti-HBs titer in obese cases was significantly lower than controls (48.5±194.5 vs. 100±557.6, P=0.012). Conclusion: The level of anti-HBs surface antigen antibody’s titer in obese cases without liver disease is lower than control group. Therefore, a suitable strategy is needed to overcome this problem, which can be the use of longer needles for vaccination.

Keywords: Hepatitis B vaccines, Obesity, Liver diseases, Immunosuppressive agent
Full-Text [PDF 559 kb]      
Type of Study: Short Communication | Subject: Molecular Immunology & Vaccines
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DOI: 10.18869/acadpub.ibj.21.3.197
PMID: 27805073
PMCID: PMC5392223


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Kabir A, Pazouki A, Jafari M, Mokhber S, Vaziri M, Alavian S M. Comparing Anti-hepatitis B Antibody Level in Iranian Obese or Overweight with Non-obese Cases. IBJ. 2017; 21 (3) :197-202
URL: http://ibj.pasteur.ac.ir/article-1-1850-en.html
Volume 21, Number 3 (5-2017) Back to browse issues page
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