:: Volume 20, Issue 5 (11-2016) ::
ibj 2016, 20(5): 246-258 Back to browse issues page
Role of Epigenetics in Biology and Human Diseases
Azam Moosavi, Ali Motevalizadeh Ardekani *

For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior plasticity, memory, cancer, autoimmune disease, and addiction as well as neurodegenerative and psychological disorders. This
review first explains the history and classification of epigenetic modifications, and then the role of epigenetic in biology and connection between the epigenetics and environment are explained. Furthermore, the role
of epigenetics in human diseases is considered by focusing on some diseases with some complicated features,
and at the end, we have given the future perspective of this field. The present review article provides concepts with some examples to reveal a broad view of different aspects of epigenetics in biology and human diseases.

Keywords: DNA modification, DNA methylation, Gene expression
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Type of Study: Review Article | Subject: Cancer Biology
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Moosavi A, Motevalizadeh Ardekani A. Role of Epigenetics in Biology and Human Diseases. ibj. 2016; 20 (5) :246-258
URL: http://ibj.pasteur.ac.ir/article-1-1747-en.html

Volume 20, Issue 5 (11-2016) Back to browse issues page
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