:: Volume 20, Issue 4 (9-2016) ::
IBJ 2016, 20(4): 223-228 Back to browse issues page
Activation of Toll-Like Receptors 2 by High-Mobility Group Box 1 in Monocytes from Patients with Ischemic Stroke
Leila Sadat-Hatamnezhad , Asghar Tanomand , Javad Mahmoudi , Siamak Sandoghchian Shotorbani
Abstract:  

Background: Stroke is a leading cause of death all around the world, and ischemic stroke is considered to be the most common stroke type. Toll-like receptors (TLRs) are important molecules for detection of both pathogen invasion and tissue damage. In this regard, the purpose of this study was to assess the expression level of TLR2 on monocytes in patients with ischemic stroke and to evaluate the expression change profile following high-mobility group box 1 (HMGB1) stimulation. Methods: A total of 30 patients with ischemic stroke were enrolled from November 2013 to September 2014. The real-time PCR and ELISA assays were applied to detect the concentrations of TLR2 mRNAs. Results: TLR2 expression was found to be increased in patients with ischemic stroke, as compared to the healthy control group (P<0.001). Also, anti-TLR2 antibodies were able to decrease the expression levels of IL-17, IL-6 and IL-33. This result implies that the enhanced TLR2 pathway and Th17 cell polarization may be due to HMGB1 stimulation in ischemic stroke. Conclusion: Further clinical studies are needed for development of a new treatment strategy to inhibit the HMGB1 pathway, thus preventing the inflammation in ischemic stroke patients.

Keywords: Toll-like receptor 2, High-mobility group box 1, Stroke
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Type of Study: Full Length | Subject: Related Fields
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DOI: 10.7508/ibj.2016.04.006
PMID: 27040385
PMCID: PMC4983677


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Sadat-Hatamnezhad L, Tanomand A, Mahmoudi J, Sandoghchian Shotorbani S. Activation of Toll-Like Receptors 2 by High-Mobility Group Box 1 in Monocytes from Patients with Ischemic Stroke. IBJ. 2016; 20 (4) :223-228
URL: http://ibj.pasteur.ac.ir/article-1-1678-en.html
Volume 20, Issue 4 (9-2016) Back to browse issues page
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