:: Volume 20, Issue 5 (11-2016) ::
IBJ 2016, 20(5): 302-306 Back to browse issues page
Demonstration of Herpes Simplex Virus, Cytomegalovirus and Epstein-Barr Virus in Colorectal Cancer
Sahar Mehrabani-Khasraghi , Mitra Ameli , Farzad Khalily
Abstract:  

Background: The present study sought to investigate molecular evidence for association between the presence of herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in CRC and colorectal polyp by using the PCR method in Iran. Methods: In this analytical case-control study, we selected 15 patients with CRC, 20 patients with colorectal polyp, and 35 patients without malignancy as controls. After DNA extraction, PCR was used to determine HSV, CMV, and EBV genome by specific primers. Statistical analysis was performed using χ2 tests. Results: Our findings demonstrated that there is no direct molecular evidence to support the association between HSV, CMV, and EBV and human colorectal malignancies. Conclusion: The results from this study do not exclude a possible oncogenic role of these viruses in neoplastic development of colon cells.

Keywords: Colorectal cancer, Herpes simplex virus, Cytomegalovirus, Epstein-Bar virus, PCR
Full-Text [PDF 431 kb]      
Type of Study: Short Communication | Subject: Cancer Biology
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Mehrabani-Khasraghi S, Ameli M, Khalily F. Demonstration of Herpes Simplex Virus, Cytomegalovirus and Epstein-Barr Virus in Colorectal Cancer. IBJ. 2016; 20 (5) :302-306
URL: http://ibj.pasteur.ac.ir/article-1-1666-en.html


Volume 20, Issue 5 (11-2016) Back to browse issues page
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