:: Volume 20, Issue 1 (1-2016) ::
IBJ 2016, 20(1): 63-67 Back to browse issues page
Role of Oxidative Stress in Modulating Unfolded Protein Response Activity in Chronic Myeloid Leukemia Cell Line
Ali Bazi , Mohammad Reza Keramati , Mehran Gholamin
Abstract:  

Background: Recently, it has been revealed that tyrosine kinase inhibitors (TKIs) act through inducing both oxidative and endoplasmic reticulum (ER) stress in chronic myeloid leukemia cells. However, ER stress signaling triggers both apoptotic and survival processes within cells. Nevertheless, mechanisms by which TKIs avoid the pro-survival effects are not clear. The aim of this study was to evaluate the potential role of oxidative stress in activity of unfolded protein response (UPR) survival pathway within K562 cell line. Methods: The expression of UPR survival target genes, Xbp1, and Grp94 (glucose requiring protein 94) was studied in single and combined exposure to oxidative and ER stress in K562 cell line by quantitative and qualitative PCR. Results: The expression of UPR-related survival gene Grp94 was hampered by exposing to oxidative stress in cell induced with ER stress. Conclusion: Interaction of oxidative and ER stress may role as a mediator influencing UPR signaling activity.

Keywords: Unfolded protein response, Oxidative stress, Endoplasmic reticulum stress
Full-Text [PDF 432 kb]      
Type of Study: Short Communication | Subject: Related Fields
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bazi A, Keramati M R, Gholamin M. Role of Oxidative Stress in Modulating Unfolded Protein Response Activity in Chronic Myeloid Leukemia Cell Line. IBJ. 2016; 20 (1) :63-67
URL: http://ibj.pasteur.ac.ir/article-1-1528-en.html


Volume 20, Issue 1 (1-2016) Back to browse issues page
Persian site map - English site map - Created in 0.17 seconds with 37 queries by YEKTAWEB 3730