:: Volume 18, Issue 2 (4-2014) ::
IBJ 2014, 18(2): 107-113 Back to browse issues page
Effect of Food Deprivation on Formalin-Induced Nociceptive Behaviors and Beta-Endorphin and Sex Hormones Concentration in Rats
Mohammad-Reza Sarookhani , Elmira Ghasemi-Dashkhasan , Nima Heidari-Oranjaghi , Hassan Azhdari-Zarmehri , Elaheh Erami , Sedighe-Sadat Hosseini
Abstract:  
Background: The present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. Also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. Methods: Food was withdrawn 48 h prior to performing the formalin test, but water continued to be available ad libitum. The formalin was injected into hind plantar paw. Results: There is significant difference between male and female control rats during phase 2B. Following 48-h food deprivation, both male and female rats exhibited enhanced nociceptive behavior in response to formalin. Food deprivation for 12 and 24 h increased and for 48 h decreased beta-endorphin level in male and female rats. Food deprivation for 24 h decreased testosterone level in male, while it had no significant effect on female rats and food deprivation for 48 h decreased testosterone level in both sexes. Food deprivation for 24 h increased estradiol level in female and that for 48 h had no significant effect on male and female rats. Conclusions: The present study demonstrates the existence of food deprivation for 48 h causes enhancement of nociception in the formalin test in male and female rats that has correlation with decrease in plasma beta-endorphin and testosterone levels.
Keywords: Rat, Food Deprivation, beta-endorphin, Naloxone
Full-Text [PDF 211 kb]      
Type of Study: Full Length | Subject: Related Fields
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Sarookhani M, Ghasemi-Dashkhasan E, Heidari-Oranjaghi N, Azhdari-Zarmehri H, Erami E, Hosseini S. Effect of Food Deprivation on Formalin-Induced Nociceptive Behaviors and Beta-Endorphin and Sex Hormones Concentration in Rats. IBJ. 2014; 18 (2) :107-113
URL: http://ibj.pasteur.ac.ir/article-1-1132-en.html


Volume 18, Issue 2 (4-2014) Back to browse issues page
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