:: Volume 16, Number 1 (2012) ::
Back to browse issues page IBJ 2012, 16(1): 33-37
XML Ultrastructural Changes of Corpus Luteum after Ovarian Stimulation at Implantation Period Print

Author(s): Mandana Beigi Boroujeni *, Nasim Beigi Boroujeni, Mojdeh Salehnia, Elahe Marandi , Masoud Beigi Boroujeni
Study Type: Original | Subject: Related Fields

DOI: 10.6091/IBJ.1033.2012     PMID: 22562030     PMCID: PMC3614258    

Article abstract:
Background: To achieve multiple oocytes for in vitro fertilization, ovulation induction is induced by gonadotropins; however, it has several effects on oocytes and embryo quality and endometrium receptivity. The aim of this study was to assess ultrastructural changes of corpus luteum after ovarian induction using human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) during luteal phase at implantation period. Methods: Female NMRI mice (6-8 weeks) were divided into control and stimulated groups. In the control group, the mice were rendered pseudopregnant and in the ovarian induction group, the mice were rendered pseudopregnant after the ovarian induction. The samples were obtained from the ovary in each group at the same time during luteal phase at implantation period. Ultrastructural changes were assessed using electron microscopy study. Results: Our results displayed some identifiable changes in ultrastructure of corpus luteum in ovarian induction group. These changes included enhancement of the apoptosis and intercellular space, whereas the angiogenesis was decreased. The findings indicated a decline in organelle density in the cytoplasm of ovarian induction, such as mitochondria, endoplasmic reticulum and polyribosome. Furthermore, chromatin condensation of nuclei was observed in some cells. Conclusion: The ovarian induction using HMG and HCG resulted in some ultrastructural changes on the corpus luteum at implantation period, which could affect on the pregnancy rate.
KeywordsCorpus luteum, Luteal phase, Ultrastructure, Ovarian induction,
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Beigi Boroujeni M, Beigi Boroujeni N, Salehnia M, Marandi E, Beigi Boroujeni M. Ultrastructural Changes of Corpus Luteum after Ovarian Stimulation at Implantation Period. IBJ. 2012; 16 (1) :33-37
URL http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-349&slc_lang=en&sid=1
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