other Related Fields Related Fields کنگره Congress <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-size:10.5pt"><span style="color:#0f1115">Dermatophytosis (tinea) affects approximately 20&ndash;25% of the global population.&nbsp;The majority of skin and nail infections are caused by the </span></span><em><span style="font-size:10.5pt"><span style="color:#0f1115">Trichophyton mentagrophytes</span></span></em><span style="font-size:10.5pt"><span style="color:#0f1115">&nbsp;complex and&nbsp;</span></span><em><span style="font-size:10.5pt"><span style="color:#0f1115">T. rubrum.</span></span></em><span style="font-size:10.5pt"><span style="color:#0f1115"> H</span></span><span style="font-size:10.5pt">owever, <span style="color:#0f1115">a novel species,&nbsp;</span></span><em><span style="font-size:10.5pt"><span style="color:#0f1115">T. indotineae</span></span></em><span style="font-size:10.5pt"><span style="color:#0f1115">, is rapidly e</span></span><span style="font-size:10.5pt">merging as a significant concern, <span style="color:#0f1115">replacing&nbsp;</span></span><em><span style="font-size:10.5pt"><span style="color:#0f1115">T. rubrum</span></span></em><span style="font-size:10.5pt"><span style="color:#0f1115">.&nbsp;</span></span><em><span style="font-size:10.5pt"><span style="color:#0f1115">T. This species poses a </span></span></em><span style="font-size:10.5pt"><span style="color:#0f1115">serious threat due to frequent r</span></span><span style="font-size:10.5pt">esistance to <span style="color:#0f1115">terbinafine resistance, w</span>hich is <span style="color:#0f1115">caused by m</span>utations in the <span style="color:#0f1115">squalene epoxidase gene. This growing resistance, especially to terbinafine, represents a g</span>lobal <span style="color:#0f1115">health concern. In Iran, for instance,&nbsp;</span></span><em><span style="font-size:10.5pt"><span style="color:#0f1115">T. indotineae</span></span></em><span style="font-size:10.5pt"><span style="color:#0f1115">&nbsp;is increasingly prevalent, with approximately 15% of isolates resistant to terbinafine. W</span>hile a<span style="color:#0f1115">lternative antifungals e</span>xist, they often come with <span style="color:#0f1115">adverse effects, and resistance t</span>o these medications is also <span style="color:#0f1115">rising, underscoring the need for safer, more effective treatments. Preclinical studies h</span>ave <span style="color:#0f1115">shown</span> <span style="color:#0f1115">that cold atmospheric plasma (CAP) can inhibit the germination of dermatophyte conidial, hinder hyphal growth, and reduce the potential for infection. Early clinical reports suggest that CAP could be a promising and safe adjunct therapy for chronic dermatophytosis, particularly in antifungal-refractory cases. To advance this evidence, our team has designed a triple-blinded randomized clinical trial to evaluate CAP&rsquo;s efficacy in treating refractory dermatophytosis. We hope this study will address significant challenges and pave the way for the future clinical adoption of CAP.</span></span></span></span></span></span></div> <br> &nbsp; <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> Antifungal resistance, Cold atmospheric plasma, Dermatophytosis, T. indotineae 55 55 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-917&slc_lang=other&sid=1 Tahereh Shokohi Yes Maryam Salimi No Zohreh Hajheidari No Anahita Mohsenpour No Seyedehniaz Hadavi No Farshad Sohbatzadeh No