Iranian Biomedical Journal

other Preclinical Assessments of Safety and Effectiveness for Cold Plasma Use in Oncology Abstract Related Fields Related Fields کنگره Congress <div style="text-align: justify;">Introduction: Plasma technology in oncology uses gas at room temperature to affect tumor tissues. This approach combines scientific insights to tackle health issues. Early findings indicated that this technology can selectively destroy pathogens while protecting healthy tissues. Current preclinical research is exploring the underlying mechanisms. Through ionization various reactive elements are generated, resulting in chemical alterations in biology and prompting different cellular behaviors. These insights enhance the ability to predict clinical outcomes effectively. Materials and Methods: Devices such as plasma jets were operated in standard laboratory environments. Mixtures of helium and oxygen were used to produce active compounds. Cancer cell lines were subjected to short exposures, and cell survival was assessed using assays such as MTT. Programmed cell death was measured using flow cytometry. In animal models, tumor-bearing mice received regular plasma treatments, and healing was evaluated through tissue section analysis. Results and Discussion: The significant effects arise from active forms of oxygen and nitrogen. Radicals such as hydroxyl radicals damage cellular components, disrupting barriers and activating internal pathways. Healthy cells respond by activating protective mechanisms that enhance recovery. In contrast, tumor cells under stress receive heightened death signals. Electric fields create temporary channels that allow for substance entry. Ultraviolet light adds genetic stress, and the dosage is critical; mild levels can speed up repair and reduce inflammation, while excessive levels pose risks of harm. Supportive cells proliferate more rapidly when exposed to this technology. Data from animal studies indicate improved tissue formation and balanced signaling molecules. The combined physical and biological actions contribute to increased reliability. Conclusion: This type of plasma technology influences biological processes through both chemical and physical mechanisms. Active forms can disrupt equilibrium, leading to beneficial or harmful effects. Evidence from laboratory and animal studies its functional mechanisms, paving the way for advancements in cancer treatment. Precise control over the application remains essential.</div>   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> Cancer therapy, Cellular responses, Cold atmospheric plasma, Preclinical investigations, Reactive species, Tissue effects 51 51 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-913&slc_lang=other&sid=1 Mohammad Mahdi Ajalli Yes