other Related Fields Related Fields کنگره Congress <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt">Introduction: </span></b><span style="font-size:10.5pt">Cutaneous warts are a common dermatological condition, and there are various treatment options available. One innovative approach is the use of cold atmospheric plasma (CAP). Unlike traditional treatments such as cryotherapy or salicylic acid, CAP does not introduce additional complications for patients. Its antimicrobial effect arises from the generation of reactive oxygen and nitrogen species. In this study, we evaluated the efficacy and safety of CAP in treating cutaneous warts.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt">Materials and Methods: </span></b><span style="font-size:10.5pt">PubMed, the Cochrane library, Embase, PEDro, Web of Science, and PROSPERO were searched for systematic reviews of randomized controlled trials (RCTs). Two reviewers independently screened the studies and extracted data. The risk of bias was assessed using the RoB 2 tool for RCTs and the ROBINS-I tool for non-randomized studies. Any discrepancies were resolved through consensus or with the help of a third reviewer.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt">Results and Discussion: </span></b><span style="font-size:10.5pt">Studies confirmed that clinical outcomes demonstrated lesion clearance after 5-7 treatment sessions, even with the short duration of plasma exposure. Complete resolution was reported in 51%-61% of cases, while partial resolution occurred in 34%-41% of cases. Tissue regeneration has shown promising therapeutic effects, but challenges remain, including small sample sizes and variability in treatment protocols, highlighting the need for larger multicenter trials. </span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt">Conclusion: </span></b><span style="font-size:10.5pt">Evidence gathered so far indicate that CAP enhances tissue repair and lowers recurrence rates through the activity of fibroblasts and keratinocytes, as well as by increasing collagen levels. This issue positions CAP as a safe and effective treatment for cutaneous warts. Patients have reported good tolerance and no significant adverse effects. These findings are expected to inform clinical practice and guide future research in this emerging field.</span></span></span></span></span></div> <br> &nbsp; <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> Cold atmospheric plasma, Cutaneous warts, Tissue regeneration 31 31 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-893&slc_lang=other&sid=1 Soheil Azarmi Giglou No Mehdi Ayuni Giglou No Aida Varghaei Yes