other Related Fields Related Fields کنگره Congress <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt">Introduction: </span></b><span style="font-size:10.5pt">The presence of residual tumor cells after surgery presents a major risk for cancer recurrence, while effective tissue repair is crucial for post-operative recovery. Cold atmospheric plasma (CAP) has emerged as a promising modality with dual functions: selectively targeting tumor cells and promoting tissue regeneration. Despite the growing interest in CAP, there is a lack of comprehensive reviews focusing on its post-surgical applications.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt">Materials and Methods: </span></b><span style="font-size:10.5pt">We conducted a systematic search of PubMed using terms related to CAP, post-surgical cancer therapy, and tissue regeneration. Studies were included if they investigated the application of CAP in post-surgical models or clinical settings, with anti-tumor and/or regenerative outcomes. The screening and selection followed PRISMA-ScR methodology. Data were extracted on study type, tumor model, plasma device used, outcomes, and mechanistic insights.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt">Results and Discussion: </span></b><span style="font-size:10.5pt">The evidence indicated that CAP could selectively induce apoptosis in residual tumor cells while enhancing wound healing, activating stem cell and promoting angiogenesis. Mechanistic studies suggest the involvement of reactive oxygen and nitrogen species, extracellular matrix remodeling, and stem cell modulation. Additionally, CAP-treated biomaterials further support tissue repair, providing a translational pathway toward clinical application.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span style="font-family:Times New Roman;"><b><span style="font-size:10.5pt">Conclusion: </span></b></span><span style="font-size:10.5pt"><span calibri="" style="font-family:"><span style="font-family:Times New Roman;">CAP demonstrates significant dual therapeutic potential in post-surgical cancer therapy by combining tumor control with regenerative benefits. The mechanistic insights support optimized application, and ongoing translational research is warranted to establish standardized protocols for clinical use.</span></span></span></span></span></span></span><br> &nbsp;</div> &nbsp; <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 29 29 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-891&slc_lang=other&sid=1 Armita Pak Yes